Drug interactions
Silodosin + Trandolapril
Severity: Moderate
Silodosin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is an alpha-1 blocker and trandolapril an ACE inhibitor, so combined use can produce additive blood pressure lowering. Orthostatic hypotension and dizziness can occur, particularly after the first doses or dose increases.
What this interaction means in plain words
Silodosin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Silodosin belongs to Genitourinary; Trandolapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering through alpha-1 adrenergic blockade and ACE inhibition.
What to do
Start the added drug at a low dose and advise the patient to rise slowly, taking the first dose at bedtime. Monitor standing and sitting blood pressure after initiation and titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Silodosin with Trandolapril?
MediHelp rates the interaction as moderate. Silodosin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin is an alpha-1 blocker and trandolapril an ACE inhibitor, so combined use can produce additive blood pressure lowering. Orthostatic hypotension and dizziness can occur, particularly after the first doses or dose increases.
How serious is the interaction between Silodosin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the added drug at a low dose and advise the patient to rise slowly, taking the first dose at bedtime. Monitor standing and sitting blood pressure after initiation and titration.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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