Drug interactions
Siltuximab + Sirolimus
Severity: Moderate
Siltuximab and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-6 with siltuximab can reverse cytokine-mediated suppression of CYP enzymes, which may lower sirolimus concentrations. This could reduce immunosuppressive effect in patients on stable sirolimus doses.
What this interaction means in plain words
Siltuximab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siltuximab belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
IL-6 inhibition normalizes CYP3A4 expression, increasing sirolimus metabolism.
What to do
Monitor sirolimus trough concentrations when starting or stopping siltuximab. Adjust the dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Siltuximab with Sirolimus?
MediHelp rates the interaction as moderate. Siltuximab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blocking IL-6 with siltuximab can reverse cytokine-mediated suppression of CYP enzymes, which may lower sirolimus concentrations. This could reduce immunosuppressive effect in patients on stable sirolimus doses.
How serious is the interaction between Siltuximab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when starting or stopping siltuximab. Adjust the dose according to levels.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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