Drug interactions
Sirolimus + Stiripentol
Severity: Moderate
Sirolimus and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so its effect on sirolimus exposure is unpredictable. Sirolimus levels may rise or fall, risking toxicity or loss of efficacy.
What this interaction means in plain words
Sirolimus and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-gp inhibition by stiripentol alters sirolimus clearance.
What to do
Monitor sirolimus trough levels closely after starting or stopping stiripentol and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Sirolimus with Stiripentol?
MediHelp rates the interaction as moderate. Sirolimus and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4 and inhibits P-glycoprotein, so its effect on sirolimus exposure is unpredictable. Sirolimus levels may rise or fall, risking toxicity or loss of efficacy.
How serious is the interaction between Sirolimus and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels closely after starting or stopping stiripentol and adjust the dose accordingly.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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