Drug interactions
Sirolimus + Trazodone
Severity: Minor
Sirolimus and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy concern is a P-glycoprotein effect of trazodone on sirolimus, but trazodone is not a recognized clinically relevant modulator of P-gp or CYP3A4 for this purpose. No meaningful change in sirolimus exposure is expected.
What this interaction means in plain words
Sirolimus and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sirolimus belongs to Miscellaneous; Trazodone belongs to Central Nervous System.
Why it happens
No established mechanism; a P-glycoprotein effect is theoretical.
What to do
No dose adjustment is required. Continue routine sirolimus trough monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Trazodone?
MediHelp rates the interaction as minor. Sirolimus and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy concern is a P-glycoprotein effect of trazodone on sirolimus, but trazodone is not a recognized clinically relevant modulator of P-gp or CYP3A4 for this purpose. No meaningful change in sirolimus exposure is expected.
How serious is the interaction between Sirolimus and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Continue routine sirolimus trough monitoring.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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