Drug interactions
Sitagliptin + Teriflunomide
Severity: Minor
Sitagliptin and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sitagliptin is eliminated mainly unchanged by the kidneys with minimal CYP2C8 involvement, so a meaningful interaction through CYP2C8 inhibition is not expected.
What this interaction means in plain words
Sitagliptin and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sitagliptin belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
No established mechanism; CYP2C8 is not a significant pathway for sitagliptin.
What to do
No dose adjustment needed; monitor glucose control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Sitagliptin with Teriflunomide?
MediHelp rates the interaction as minor. Sitagliptin and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sitagliptin is eliminated mainly unchanged by the kidneys with minimal CYP2C8 involvement, so a meaningful interaction through CYP2C8 inhibition is not expected.
How serious is the interaction between Sitagliptin and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; monitor glucose control as usual.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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