Drug interactions
Sodium zirconium cyclosilicate + Tolbutamide
Severity: Minor
Sodium zirconium cyclosilicate and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate transiently raises gastric pH, which could alter absorption of drugs with pH-dependent solubility. Tolbutamide is a weak acid, so the effect on its absorption is uncertain and probably small.
What this interaction means in plain words
Sodium zirconium cyclosilicate and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sodium zirconium cyclosilicate belongs to Miscellaneous; Tolbutamide belongs to Endocrine.
Why it happens
Elevated gastric pH may alter dissolution and absorption of pH-sensitive drugs.
What to do
Give tolbutamide at least 2 hours before or after sodium zirconium cyclosilicate and monitor blood glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Sodium zirconium cyclosilicate with Tolbutamide?
MediHelp rates the interaction as minor. Sodium zirconium cyclosilicate and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate transiently raises gastric pH, which could alter absorption of drugs with pH-dependent solubility. Tolbutamide is a weak acid, so the effect on its absorption is uncertain and probably small.
How serious is the interaction between Sodium zirconium cyclosilicate and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give tolbutamide at least 2 hours before or after sodium zirconium cyclosilicate and monitor blood glucose.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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