Drug interactions
Sofosbuvir + Tipranavir
Severity: Major
Sofosbuvir and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, induces P-gp and can reduce sofosbuvir exposure. This may reduce antiviral efficacy.
What this interaction means in plain words
Sofosbuvir and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sofosbuvir belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir induces intestinal P-gp, decreasing sofosbuvir absorption.
What to do
Avoid coadministration; use an alternative HIV regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Sofosbuvir with Tipranavir?
MediHelp rates the interaction as major. Sofosbuvir and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, induces P-gp and can reduce sofosbuvir exposure. This may reduce antiviral efficacy.
How serious is the interaction between Sofosbuvir and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; use an alternative HIV regimen.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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