Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Stiripentol
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits BCRP and P-glycoprotein, which transport sofosbuvir, velpatasvir and voxilaprevir. Exposure to these antivirals may increase, raising the possibility of adverse effects such as headache, fatigue and nausea.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits intestinal BCRP and P-gp efflux, increasing absorption and exposure of the antiviral components.
What to do
Monitor for adverse effects of the antiviral regimen during coadministration. Reassess if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Stiripentol?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits BCRP and P-glycoprotein, which transport sofosbuvir, velpatasvir and voxilaprevir. Exposure to these antivirals may increase, raising the possibility of adverse effects such as headache, fatigue and nausea.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the antiviral regimen during coadministration. Reassess if tolerability problems arise.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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