Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Vadadustat
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and can increase exposure to BCRP substrates such as sofosbuvir and velpatasvir. The clinical impact is probably modest, but adverse effects of the antiviral may be more likely.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits BCRP, decreasing efflux of sofosbuvir and velpatasvir.
What to do
Monitor for antiviral adverse effects such as headache, fatigue and nausea. No empirical dose change is standard for the antivirals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Vadadustat?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and can increase exposure to BCRP substrates such as sofosbuvir and velpatasvir. The clinical impact is probably modest, but adverse effects of the antiviral may be more likely.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antiviral adverse effects such as headache, fatigue and nausea. No empirical dose change is standard for the antivirals.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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