Drug interactions
Solifenacin + Sotalol
Severity: Major
Solifenacin and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a class III antiarrhythmic with a strong, dose-dependent risk of QT prolongation and torsades de pointes. Adding solifenacin, which has a small QT effect, may further raise that risk.
What this interaction means in plain words
Solifenacin and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Solifenacin belongs to Genitourinary; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation on top of potassium channel blockade by sotalol.
What to do
Prefer a non-QT-prolonging alternative for bladder symptoms, such as mirabegron. If both must be used, monitor the ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Solifenacin with Sotalol?
MediHelp rates the interaction as major. Solifenacin and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a class III antiarrhythmic with a strong, dose-dependent risk of QT prolongation and torsades de pointes. Adding solifenacin, which has a small QT effect, may further raise that risk.
How serious is the interaction between Solifenacin and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging alternative for bladder symptoms, such as mirabegron. If both must be used, monitor the ECG and keep potassium and magnesium within normal range.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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