Drug interactions
Solifenacin + Tiotropium-olodaterol
Severity: Moderate
Solifenacin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin is an antimuscarinic and adds to tiotropium anticholinergic effects, including dry mouth, constipation, urinary retention and blurred vision. The risk is higher in older adults and those with glaucoma or prostatic hypertrophy.
What this interaction means in plain words
Solifenacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for urinary retention, constipation and eye symptoms. Consider dose reduction or an alternative bladder agent if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Solifenacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin is an antimuscarinic and adds to tiotropium anticholinergic effects, including dry mouth, constipation, urinary retention and blurred vision. The risk is higher in older adults and those with glaucoma or prostatic hypertrophy.
How serious is the interaction between Solifenacin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and eye symptoms. Consider dose reduction or an alternative bladder agent if effects occur.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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