Drug interactions
Solifenacin + Trimipramine
Severity: Major
Solifenacin and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with substantial anticholinergic activity and can prolong the QT interval. Combined with solifenacin it increases the risk of anticholinergic toxicity and arrhythmia.
What this interaction means in plain words
Solifenacin and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Solifenacin belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Avoid the combination where an alternative exists, especially in older patients or those with cardiac disease. If both are needed, monitor the ECG and watch for urinary retention, constipation and confusion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Solifenacin with Trimipramine?
MediHelp rates the interaction as major. Solifenacin and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trimipramine is a tricyclic antidepressant with substantial anticholinergic activity and can prolong the QT interval. Combined with solifenacin it increases the risk of anticholinergic toxicity and arrhythmia.
How serious is the interaction between Solifenacin and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists, especially in older patients or those with cardiac disease. If both are needed, monitor the ECG and watch for urinary retention, constipation and confusion.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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