Drug interactions
Sonidegib + Zileuton
Severity: Moderate
Sonidegib and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton, a weak CYP3A4 inhibitor, may increase sonidegib exposure. Higher levels raise the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
What this interaction means in plain words
Sonidegib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sonidegib belongs to Oncology; Zileuton belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 by zileuton reduces sonidegib metabolism.
What to do
Monitor for muscle pain, weakness and creatine kinase elevation, and avoid prolonged coadministration where possible. Interrupt sonidegib if significant muscle toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Sonidegib with Zileuton?
MediHelp rates the interaction as moderate. Sonidegib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton, a weak CYP3A4 inhibitor, may increase sonidegib exposure. Higher levels raise the risk of musculoskeletal toxicity such as myopathy and creatine kinase elevation.
How serious is the interaction between Sonidegib and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and creatine kinase elevation, and avoid prolonged coadministration where possible. Interrupt sonidegib if significant muscle toxicity develops.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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