Drug interactions
Sotagliflozin + Tolazamide
Severity: Moderate
Sotagliflozin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding sotagliflozin to a sulfonylurea such as tolazamide lowers blood glucose further and increases the chance of hypoglycemia. The risk is greatest in patients with tight glycemic control, reduced renal function or poor oral intake.
What this interaction means in plain words
Sotagliflozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotagliflozin belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effect, with sulfonylurea-driven insulin secretion combined with SGLT-mediated glucosuria.
What to do
Consider reducing the tolazamide dose when starting sotagliflozin and monitor blood glucose. Teach the patient to recognise and treat hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
Frequently asked questions
Can I take Sotagliflozin with Tolazamide?
MediHelp rates the interaction as moderate. Sotagliflozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding sotagliflozin to a sulfonylurea such as tolazamide lowers blood glucose further and increases the chance of hypoglycemia. The risk is greatest in patients with tight glycemic control, reduced renal function or poor oral intake.
How serious is the interaction between Sotagliflozin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolazamide dose when starting sotagliflozin and monitor blood glucose. Teach the patient to recognise and treat hypoglycemia.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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