Drug interactions
Sotagliflozin + Tolbutamide
Severity: Moderate
Sotagliflozin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin lowers glucose independently of insulin, so combining it with a sulfonylurea increases the risk of hypoglycemia. The risk is greater with tight baseline control.
What this interaction means in plain words
Sotagliflozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotagliflozin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-induced insulin secretion and SGLT inhibitor-induced glucosuria.
What to do
Consider reducing the tolbutamide dose when sotagliflozin is started. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
Frequently asked questions
Can I take Sotagliflozin with Tolbutamide?
MediHelp rates the interaction as moderate. Sotagliflozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin lowers glucose independently of insulin, so combining it with a sulfonylurea increases the risk of hypoglycemia. The risk is greater with tight baseline control.
How serious is the interaction between Sotagliflozin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolbutamide dose when sotagliflozin is started. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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