Drug interactions
Sotalol + Tacrolimus
Severity: Moderate
Sotalol and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval and cause hyperkalemia or hypomagnesemia, which affects arrhythmia risk. Combined with sotalol, the risk of QT-related arrhythmia may increase.
What this interaction means in plain words
Sotalol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotalol belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive QT prolongation, with tacrolimus-related electrolyte disturbances adding to the risk.
What to do
Monitor ECG, potassium and magnesium, and tacrolimus trough levels. Replace magnesium as needed and consider an alternative antiarrhythmic if QTc increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Sotalol with Tacrolimus?
MediHelp rates the interaction as moderate. Sotalol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval and cause hyperkalemia or hypomagnesemia, which affects arrhythmia risk. Combined with sotalol, the risk of QT-related arrhythmia may increase.
How serious is the interaction between Sotalol and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and tacrolimus trough levels. Replace magnesium as needed and consider an alternative antiarrhythmic if QTc increases.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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