Drug interactions
Sotalol + Tizanidine
Severity: Moderate
Sotalol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine and sotalol both lower blood pressure and heart rate, so combined use may cause hypotension and bradycardia. Because sotalol also prolongs the QT interval, symptomatic bradycardia and hypotension are of added concern.
What this interaction means in plain words
Sotalol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotalol belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects of central alpha-2 agonism and beta blockade.
What to do
Monitor blood pressure, heart rate and ECG when starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Tizanidine?
MediHelp rates the interaction as moderate. Sotalol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine and sotalol both lower blood pressure and heart rate, so combined use may cause hypotension and bradycardia. Because sotalol also prolongs the QT interval, symptomatic bradycardia and hypotension are of added concern.
How serious is the interaction between Sotalol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when starting or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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