Drug interactions
Sotalol + Trimethoprim
Severity: Moderate
Sotalol and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim has been linked to QT prolongation in some reports and can raise potassium, which may increase arrhythmia risk. With sotalol, these effects may add up, particularly in older patients or those with renal impairment.
What this interaction means in plain words
Sotalol and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotalol belongs to Cardiovascular; Trimethoprim belongs to Anti Bacterial.
Why it happens
Possible additive QT prolongation, with trimethoprim-related hyperkalemia as a further contributor.
What to do
Monitor potassium, renal function and ECG if the combination is used, and consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Sotalol with Trimethoprim?
MediHelp rates the interaction as moderate. Sotalol and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim has been linked to QT prolongation in some reports and can raise potassium, which may increase arrhythmia risk. With sotalol, these effects may add up, particularly in older patients or those with renal impairment.
How serious is the interaction between Sotalol and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, renal function and ECG if the combination is used, and consider an alternative antibiotic in high-risk patients.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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