Drug interactions
Stiripentol + Tacrolimus
Severity: Moderate
Stiripentol and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and P-glycoprotein but can also induce CYP3A4, so tacrolimus concentrations may rise or fall unpredictably. Both subtherapeutic and toxic exposure are possible.
What this interaction means in plain words
Stiripentol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Mixed CYP3A4 inhibition and induction plus P-glycoprotein inhibition by stiripentol alters tacrolimus clearance and absorption.
What to do
Measure tacrolimus trough levels before and frequently after starting or stopping stiripentol. Adjust the tacrolimus dose to maintain target concentrations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tacrolimus?
MediHelp rates the interaction as moderate. Stiripentol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP3A4 and P-glycoprotein but can also induce CYP3A4, so tacrolimus concentrations may rise or fall unpredictably. Both subtherapeutic and toxic exposure are possible.
How serious is the interaction between Stiripentol and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure tacrolimus trough levels before and frequently after starting or stopping stiripentol. Adjust the tacrolimus dose to maintain target concentrations.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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