Drug interactions
Stiripentol + Tizanidine
Severity: Moderate
Stiripentol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP1A2 activity and may change tizanidine exposure, with inhibition raising levels and risking hypotension and bradycardia. Both drugs also cause sedation, so drowsiness may be additive.
What this interaction means in plain words
Stiripentol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Stiripentol modulates CYP1A2 metabolism of tizanidine, plus additive CNS depression.
What to do
Monitor blood pressure, heart rate, sedation and spasticity response, and adjust the tizanidine dose accordingly. Counsel patients about drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tizanidine?
MediHelp rates the interaction as moderate. Stiripentol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP1A2 activity and may change tizanidine exposure, with inhibition raising levels and risking hypotension and bradycardia. Both drugs also cause sedation, so drowsiness may be additive.
How serious is the interaction between Stiripentol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, sedation and spasticity response, and adjust the tizanidine dose accordingly. Counsel patients about drowsiness and driving.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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