Drug interactions
Stiripentol + Upadacitinib
Severity: Minor
Stiripentol and Upadacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP3A4 in vitro, and may modestly raise upadacitinib concentrations. The clinical significance is uncertain, but greater JAK inhibition could increase infection and hematologic risk.
What this interaction means in plain words
Stiripentol and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Stiripentol belongs to Central Nervous System; Upadacitinib belongs to Musculoskeletal.
Why it happens
Possible inhibition of CYP3A4-mediated upadacitinib metabolism; clinical effect not well established.
What to do
No empirical dose change is required; monitor for infections and cytopenias if both drugs are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Upadacitinib?
MediHelp rates the interaction as minor. Stiripentol and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits several CYP enzymes including CYP3A4 in vitro, and may modestly raise upadacitinib concentrations. The clinical significance is uncertain, but greater JAK inhibition could increase infection and hematologic risk.
How serious is the interaction between Stiripentol and Upadacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required; monitor for infections and cytopenias if both drugs are used together.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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