Drug interactions
Stiripentol + Voriconazole
Severity: Moderate
Stiripentol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is partly metabolized by several CYP enzymes, including CYP3A4, so voriconazole may raise its levels. Stiripentol itself inhibits CYP2C19 and CYP3A4 and may increase voriconazole exposure in turn. Effects may include sedation, ataxia, and azole toxicity.
What this interaction means in plain words
Stiripentol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and CYP2C19 metabolism of stiripentol, and stiripentol may inhibit voriconazole clearance.
What to do
Monitor for sedation, ataxia, and voriconazole adverse effects such as visual and hepatic effects. Consider voriconazole trough monitoring and a stiripentol dose reduction if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Voriconazole?
MediHelp rates the interaction as moderate. Stiripentol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is partly metabolized by several CYP enzymes, including CYP3A4, so voriconazole may raise its levels. Stiripentol itself inhibits CYP2C19 and CYP3A4 and may increase voriconazole exposure in turn. Effects may include sedation, ataxia, and azole toxicity.
How serious is the interaction between Stiripentol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia, and voriconazole adverse effects such as visual and hepatic effects. Consider voriconazole trough monitoring and a stiripentol dose reduction if toxicity appears.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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