Drug interactions
Sumatriptan + Vilazodone
Severity: Moderate
Sumatriptan and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase serotonergic activity, so using them together raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. The risk is highest when starting or increasing doses.
What this interaction means in plain words
Sumatriptan and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sumatriptan belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects of an SSRI/5-HT1A partial agonist and a 5-HT1B/1D agonist.
What to do
If both are needed, educate the patient on serotonin syndrome symptoms and monitor closely after dose changes. Stop both drugs and provide supportive care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Sumatriptan with Vilazodone?
MediHelp rates the interaction as moderate. Sumatriptan and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase serotonergic activity, so using them together raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia and autonomic instability. The risk is highest when starting or increasing doses.
How serious is the interaction between Sumatriptan and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, educate the patient on serotonin syndrome symptoms and monitor closely after dose changes. Stop both drugs and provide supportive care if symptoms appear.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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