Drug interactions
Tacrolimus + Tiotropium-olodaterol
Severity: Moderate
Tacrolimus and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval, and olodaterol may add to cardiac stimulation and lower potassium. The combination may raise arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Tacrolimus and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic effects on QT interval and beta2-mediated hypokalemia.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors; correct low potassium or magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Tacrolimus and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval, and olodaterol may add to cardiac stimulation and lower potassium. The combination may raise arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Tacrolimus and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors; correct low potassium or magnesium.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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