Drug interactions
Tacrolimus + Triclabendazole
Severity: Moderate
Tacrolimus and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may increase the risk of arrhythmia. The risk is higher with electrolyte disturbances or heart disease.
What this interaction means in plain words
Tacrolimus and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive prolongation of the QT interval.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor ECG during the short triclabendazole course in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Tacrolimus with Triclabendazole?
MediHelp rates the interaction as moderate. Tacrolimus and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may increase the risk of arrhythmia. The risk is higher with electrolyte disturbances or heart disease.
How serious is the interaction between Tacrolimus and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor ECG during the short triclabendazole course in patients with other risk factors.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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