Drug interactions
Tacrolimus + Trimipramine
Severity: Moderate
Tacrolimus and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may increase arrhythmia risk, especially with hypokalaemia or hypomagnesaemia, which tacrolimus can cause. Some tricyclics may also modestly influence tacrolimus levels.
What this interaction means in plain words
Tacrolimus and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tacrolimus belongs to Miscellaneous; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, aggravated by tacrolimus-related electrolyte disturbance.
What to do
Monitor ECG, potassium and magnesium, and check tacrolimus trough levels when starting or stopping trimipramine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Trimipramine?
MediHelp rates the interaction as moderate. Tacrolimus and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may increase arrhythmia risk, especially with hypokalaemia or hypomagnesaemia, which tacrolimus can cause. Some tricyclics may also modestly influence tacrolimus levels.
How serious is the interaction between Tacrolimus and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and check tacrolimus trough levels when starting or stopping trimipramine.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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