Drug interactions
Talazoparib + Verapamil
Severity: Moderate
Talazoparib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talazoparib is a P-gp substrate, and verapamil inhibits P-gp. Co-administration can increase talazoparib exposure and the risk of myelosuppression.
What this interaction means in plain words
Talazoparib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Talazoparib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits P-gp-mediated efflux of talazoparib, increasing its absorption and reducing its clearance.
What to do
Where possible choose an alternative to verapamil. If it is unavoidable, reduce the talazoparib dose as per labeling and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Talazoparib and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Talazoparib with Verapamil?
MediHelp rates the interaction as moderate. Talazoparib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talazoparib is a P-gp substrate, and verapamil inhibits P-gp. Co-administration can increase talazoparib exposure and the risk of myelosuppression.
How serious is the interaction between Talazoparib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative to verapamil. If it is unavoidable, reduce the talazoparib dose as per labeling and monitor blood counts.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
