Drug interactions
Tamsulosin + Ticlopidine
Severity: Moderate
Tamsulosin and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2D6 (and CYP2C19) and may increase tamsulosin exposure. This may cause dizziness and orthostatic hypotension.
What this interaction means in plain words
Tamsulosin and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamsulosin belongs to Genitourinary; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2D6, reducing tamsulosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce the tamsulosin dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Tamsulosin with Ticlopidine?
MediHelp rates the interaction as moderate. Tamsulosin and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2D6 (and CYP2C19) and may increase tamsulosin exposure. This may cause dizziness and orthostatic hypotension.
How serious is the interaction between Tamsulosin and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce the tamsulosin dose if symptomatic.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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