Drug interactions
Tapentadol + Tedizolid
Severity: Major
Tapentadol and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, and with tapentadol it may increase the risk of serotonin syndrome or noradrenergic excess. Clinical studies of tedizolid showed little serotonergic effect, so the risk is probably lower than with linezolid but remains a concern.
What this interaction means in plain words
Tapentadol and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tapentadol belongs to Musculoskeletal; Tedizolid belongs to Anti Bacterial.
Why it happens
Weak MAO inhibition by tedizolid adds to tapentadol's serotonergic and noradrenergic reuptake inhibition.
What to do
Avoid if alternatives exist. If both are needed, monitor for signs of serotonin toxicity and blood pressure changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Tapentadol with Tedizolid?
MediHelp rates the interaction as major. Tapentadol and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tedizolid is a weak reversible MAO inhibitor, and with tapentadol it may increase the risk of serotonin syndrome or noradrenergic excess. Clinical studies of tedizolid showed little serotonergic effect, so the risk is probably lower than with linezolid but remains a concern.
How serious is the interaction between Tapentadol and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist. If both are needed, monitor for signs of serotonin toxicity and blood pressure changes.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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