Drug interactions
Tazemetostat + Temsirolimus
Severity: Moderate
Tazemetostat and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and a CYP3A4 substrate, while temsirolimus is a CYP3A4 substrate with its own metabolite sirolimus. Exposure of temsirolimus may fall, and the effect of temsirolimus on tazemetostat is uncertain.
What this interaction means in plain words
Tazemetostat and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tazemetostat belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Tazemetostat induces CYP3A4, increasing temsirolimus clearance, and competition for the same pathway may affect tazemetostat levels.
What to do
Monitor tumor response and adverse effects of both agents. Adjust doses based on clinical response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Temsirolimus?
MediHelp rates the interaction as moderate. Tazemetostat and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and a CYP3A4 substrate, while temsirolimus is a CYP3A4 substrate with its own metabolite sirolimus. Exposure of temsirolimus may fall, and the effect of temsirolimus on tazemetostat is uncertain.
How serious is the interaction between Tazemetostat and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and adverse effects of both agents. Adjust doses based on clinical response and tolerability.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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