Drug interactions
Tazemetostat + Tramadol
Severity: Minor
Tazemetostat and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly reduce tramadol exposure. This could lessen analgesic effect.
What this interaction means in plain words
Tazemetostat and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Tramadol belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by tazemetostat increases tramadol metabolism.
What to do
Monitor analgesic response and adjust the tramadol dose if pain control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Tramadol?
MediHelp rates the interaction as minor. Tazemetostat and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly reduce tramadol exposure. This could lessen analgesic effect.
How serious is the interaction between Tazemetostat and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust the tramadol dose if pain control is inadequate.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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