Drug interactions
Tazemetostat + Trazodone
Severity: Minor
Tazemetostat and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower trazodone concentrations, reducing its effect. Trazodone is not a meaningful CYP3A4 inhibitor, so the reverse effect is unlikely.
What this interaction means in plain words
Tazemetostat and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Trazodone belongs to Central Nervous System.
Why it happens
CYP3A4 induction by tazemetostat increases trazodone metabolism.
What to do
Monitor for reduced response to trazodone and increase the dose if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Trazodone?
MediHelp rates the interaction as minor. Tazemetostat and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower trazodone concentrations, reducing its effect. Trazodone is not a meaningful CYP3A4 inhibitor, so the reverse effect is unlikely.
How serious is the interaction between Tazemetostat and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to trazodone and increase the dose if clinically needed.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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