Drug interactions
Tazemetostat + Vortioxetine
Severity: Minor
Tazemetostat and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may reduce vortioxetine exposure slightly. Clinical impact is likely small given vortioxetine's main CYP2D6 clearance.
What this interaction means in plain words
Tazemetostat and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Vortioxetine belongs to Central Nervous System.
Why it happens
Tazemetostat induces CYP3A4, modestly increasing vortioxetine metabolism.
What to do
No routine adjustment; monitor for loss of antidepressant response and adjust the vortioxetine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Vortioxetine?
MediHelp rates the interaction as minor. Tazemetostat and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may reduce vortioxetine exposure slightly. Clinical impact is likely small given vortioxetine's main CYP2D6 clearance.
How serious is the interaction between Tazemetostat and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for loss of antidepressant response and adjust the vortioxetine dose if needed.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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