Drug interactions
Tazemetostat + Zileuton
Severity: Moderate
Tazemetostat and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized mainly by CYP3A4, and zileuton is a weak inhibitor of this enzyme. Tazemetostat exposure may increase modestly, raising the risk of its adverse effects.
What this interaction means in plain words
Tazemetostat and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tazemetostat belongs to Miscellaneous; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP3A4, reducing tazemetostat metabolism.
What to do
Monitor for tazemetostat toxicity such as cytopenias and secondary malignancy signs; consider an alternative to zileuton if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Zileuton?
MediHelp rates the interaction as moderate. Tazemetostat and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is metabolized mainly by CYP3A4, and zileuton is a weak inhibitor of this enzyme. Tazemetostat exposure may increase modestly, raising the risk of its adverse effects.
How serious is the interaction between Tazemetostat and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat toxicity such as cytopenias and secondary malignancy signs; consider an alternative to zileuton if possible.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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