Drug interactions
Teclistamab + Thioridazine
Severity: Moderate
Teclistamab and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab induces cytokine release that can temporarily suppress CYP450 enzymes and increase exposure to sensitive substrates. Higher thioridazine levels would raise the risk of QT prolongation.
What this interaction means in plain words
Teclistamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teclistamab belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP450 activity, reducing thioridazine metabolism during cytokine release.
What to do
Monitor for thioridazine toxicity and QTc around step-up dosing and during cytokine release syndrome, reducing the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Teclistamab with Thioridazine?
MediHelp rates the interaction as moderate. Teclistamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab induces cytokine release that can temporarily suppress CYP450 enzymes and increase exposure to sensitive substrates. Higher thioridazine levels would raise the risk of QT prolongation.
How serious is the interaction between Teclistamab and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thioridazine toxicity and QTc around step-up dosing and during cytokine release syndrome, reducing the dose if needed.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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