Drug interactions
Teclistamab + Valproic acid
Severity: Minor
Teclistamab and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release from teclistamab can transiently suppress CYP enzymes, but valproate relies mostly on non-CYP clearance, so exposure changes are expected to be small. Overlapping thrombocytopenia and liver effects may be relevant.
What this interaction means in plain words
Teclistamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Teclistamab belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Cytokine-mediated CYP suppression of limited relevance to valproate.
What to do
Monitor valproate levels, liver enzymes and platelet counts around step-up dosing and during cytokine release syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Teclistamab with Valproic acid?
MediHelp rates the interaction as minor. Teclistamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cytokine release from teclistamab can transiently suppress CYP enzymes, but valproate relies mostly on non-CYP clearance, so exposure changes are expected to be small. Overlapping thrombocytopenia and liver effects may be relevant.
How serious is the interaction between Teclistamab and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor valproate levels, liver enzymes and platelet counts around step-up dosing and during cytokine release syndrome.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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