Drug interactions
Teclistamab + Warfarin
Severity: Moderate
Teclistamab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab induces cytokine release that can temporarily suppress CYP450 activity. Warfarin levels and INR may rise, increasing the risk of bleeding, especially around cytokine release syndrome.
What this interaction means in plain words
Teclistamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teclistamab belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Cytokine-mediated suppression of hepatic CYP450 enzymes reduces warfarin metabolism.
What to do
Monitor INR more frequently after teclistamab step-up doses and during cytokine release syndrome. Adjust the warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Teclistamab with Warfarin?
MediHelp rates the interaction as moderate. Teclistamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab induces cytokine release that can temporarily suppress CYP450 activity. Warfarin levels and INR may rise, increasing the risk of bleeding, especially around cytokine release syndrome.
How serious is the interaction between Teclistamab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently after teclistamab step-up doses and during cytokine release syndrome. Adjust the warfarin dose as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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