Drug interactions
Tedizolid + Zolmitriptan
Severity: Moderate
Tedizolid and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolmitriptan is a 5-HT1B/1D agonist, and its active metabolite is cleared partly by MAO-A. Weak MAO inhibition by tedizolid could raise exposure and add serotonergic effects. Clinically important effects appear uncommon.
What this interaction means in plain words
Tedizolid and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tedizolid belongs to Anti Bacterial; Zolmitriptan belongs to Central Nervous System.
Why it happens
Weak MAO-A inhibition by tedizolid may reduce zolmitriptan clearance and add serotonergic activity.
What to do
Monitor for serotonin toxicity and limit triptan doses. Prefer a non-serotonergic antibiotic if practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Tedizolid with Zolmitriptan?
MediHelp rates the interaction as moderate. Tedizolid and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zolmitriptan is a 5-HT1B/1D agonist, and its active metabolite is cleared partly by MAO-A. Weak MAO inhibition by tedizolid could raise exposure and add serotonergic effects. Clinically important effects appear uncommon.
How serious is the interaction between Tedizolid and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and limit triptan doses. Prefer a non-serotonergic antibiotic if practical.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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