Drug interactions
Temazepam + Trazodone
Severity: Moderate
Temazepam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, and taking them together can increase drowsiness, cognitive impairment and fall risk. This matters most in older patients and with night-time dosing.
What this interaction means in plain words
Temazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temazepam belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and trazodone's antihistaminic and alpha-blocking actions.
What to do
Use the lowest effective doses and avoid alcohol. Monitor for daytime sedation and falls, especially in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Temazepam with Trazodone?
MediHelp rates the interaction as moderate. Temazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, and taking them together can increase drowsiness, cognitive impairment and fall risk. This matters most in older patients and with night-time dosing.
How serious is the interaction between Temazepam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid alcohol. Monitor for daytime sedation and falls, especially in the elderly.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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