Drug interactions
Temozolomide + Trastuzumab deruxtecan
Severity: Moderate
Temozolomide and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and temozolomide is also myelosuppressive. Together they may increase the incidence and severity of neutropenia, lymphopenia and thrombocytopenia, raising infection risk.
What this interaction means in plain words
Temozolomide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temozolomide belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive bone marrow suppression from the topoisomerase I inhibitor payload and the alkylating agent.
What to do
Check complete blood counts regularly and hold or reduce doses per labeling for severe neutropenia. Educate patients to report fever promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temozolomide
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Temozolomide with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Temozolomide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and temozolomide is also myelosuppressive. Together they may increase the incidence and severity of neutropenia, lymphopenia and thrombocytopenia, raising infection risk.
How serious is the interaction between Temozolomide and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts regularly and hold or reduce doses per labeling for severe neutropenia. Educate patients to report fever promptly.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
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