Drug interactions
Temsirolimus + Trastuzumab deruxtecan
Severity: Moderate
Temsirolimus and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause myelosuppression and immunosuppression, and together may increase neutropenia and risk of serious infection. Both are also linked to interstitial lung disease or pneumonitis, so combined pulmonary toxicity is a concern.
What this interaction means in plain words
Temsirolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive effects, with overlapping risk of pneumonitis.
What to do
Monitor blood counts and respiratory symptoms regularly. Interrupt or reduce therapy for severe neutropenia, infection or suspected pneumonitis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Temsirolimus and Trastuzumab deruxtecan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Temsirolimus with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Temsirolimus and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause myelosuppression and immunosuppression, and together may increase neutropenia and risk of serious infection. Both are also linked to interstitial lung disease or pneumonitis, so combined pulmonary toxicity is a concern.
How serious is the interaction between Temsirolimus and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and respiratory symptoms regularly. Interrupt or reduce therapy for severe neutropenia, infection or suspected pneumonitis.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
