Drug interactions
Tepotinib + Topotecan
Severity: Moderate
Tepotinib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein, and topotecan is a P-gp substrate. Topotecan exposure may increase, with greater risk of myelosuppression.
What this interaction means in plain words
Tepotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tepotinib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Tepotinib inhibits P-gp efflux, increasing topotecan absorption and decreasing its elimination.
What to do
Avoid oral topotecan with tepotinib; with IV topotecan monitor complete blood counts and reduce dose if neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Tepotinib with Topotecan?
MediHelp rates the interaction as moderate. Tepotinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein, and topotecan is a P-gp substrate. Topotecan exposure may increase, with greater risk of myelosuppression.
How serious is the interaction between Tepotinib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral topotecan with tepotinib; with IV topotecan monitor complete blood counts and reduce dose if neutropenia occurs.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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