Drug interactions
Tepotinib + Verapamil
Severity: Moderate
Tepotinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp, and verapamil is a P-gp substrate, so verapamil exposure may increase. This could heighten bradycardia, AV block and hypotension.
What this interaction means in plain words
Tepotinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tepotinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Tepotinib inhibits intestinal and other P-gp, reducing verapamil efflux.
What to do
Monitor heart rate, ECG and blood pressure after starting tepotinib. Reduce the verapamil dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Tepotinib with Verapamil?
MediHelp rates the interaction as moderate. Tepotinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-gp, and verapamil is a P-gp substrate, so verapamil exposure may increase. This could heighten bradycardia, AV block and hypotension.
How serious is the interaction between Tepotinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and blood pressure after starting tepotinib. Reduce the verapamil dose if bradycardia or hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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