Drug interactions
Tepotinib + Vinblastine
Severity: Moderate
Tepotinib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase exposure to vinblastine. This may heighten myelosuppression and neurotoxicity.
What this interaction means in plain words
Tepotinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tepotinib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Tepotinib inhibits P-gp efflux of vinblastine.
What to do
Monitor blood counts and signs of neurotoxicity. Reduce the vinblastine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Tepotinib with Vinblastine?
MediHelp rates the interaction as moderate. Tepotinib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may increase exposure to vinblastine. This may heighten myelosuppression and neurotoxicity.
How serious is the interaction between Tepotinib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neurotoxicity. Reduce the vinblastine dose if toxicity occurs.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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