Drug interactions
Teriflunomide + Treprostinil
Severity: Minor
Teriflunomide and Treprostinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C8, which contributes to treprostinil metabolism, so treprostinil exposure could rise. This may increase vasodilatory effects such as hypotension, headache and flushing.
What this interaction means in plain words
Teriflunomide and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Teriflunomide belongs to Central Nervous System; Treprostinil belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP2C8-mediated treprostinil metabolism by teriflunomide.
What to do
Monitor blood pressure and for vasodilatory adverse effects, and adjust the treprostinil dose to tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Treprostinil
Frequently asked questions
Can I take Teriflunomide with Treprostinil?
MediHelp rates the interaction as minor. Teriflunomide and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide inhibits CYP2C8, which contributes to treprostinil metabolism, so treprostinil exposure could rise. This may increase vasodilatory effects such as hypotension, headache and flushing.
How serious is the interaction between Teriflunomide and Treprostinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for vasodilatory adverse effects, and adjust the treprostinil dose to tolerability.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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