Drug interactions
Ticagrelor + Ticlopidine
Severity: Major
Ticagrelor and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit platelet P2Y12 receptors, so using them together adds antiplatelet effect without a clear benefit. Bleeding risk rises, and ticlopidine also carries a risk of hematologic toxicity.
What this interaction means in plain words
Ticagrelor and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ticagrelor belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive P2Y12 receptor blockade causing duplicated antiplatelet pharmacodynamic effects.
What to do
Avoid combining two P2Y12 inhibitors; choose a single agent. If a switch is needed, follow recommended transition protocols and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Ticagrelor with Ticlopidine?
MediHelp rates the interaction as major. Ticagrelor and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs inhibit platelet P2Y12 receptors, so using them together adds antiplatelet effect without a clear benefit. Bleeding risk rises, and ticlopidine also carries a risk of hematologic toxicity.
How serious is the interaction between Ticagrelor and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two P2Y12 inhibitors; choose a single agent. If a switch is needed, follow recommended transition protocols and monitor for bleeding.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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