Drug interactions
Ticlopidine + Tolbutamide
Severity: Minor
Ticlopidine and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C9 and CYP2C19 to some extent and may raise tolbutamide concentrations, possibly enhancing its hypoglycemic effect. Reported clinical impact is limited.
What this interaction means in plain words
Ticlopidine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ticlopidine belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated tolbutamide metabolism by ticlopidine.
What to do
Monitor blood glucose when starting or stopping ticlopidine and reduce tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticlopidine
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Ticlopidine with Tolbutamide?
MediHelp rates the interaction as minor. Ticlopidine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticlopidine inhibits CYP2C9 and CYP2C19 to some extent and may raise tolbutamide concentrations, possibly enhancing its hypoglycemic effect. Reported clinical impact is limited.
How serious is the interaction between Ticlopidine and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping ticlopidine and reduce tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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