Drug interactions
Ticlopidine + Voxelotor
Severity: Moderate
Ticlopidine and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure of sensitive CYP3A4 substrates. Ticlopidine is partly metabolized by CYP3A4, so exposure may change. The clinical significance is uncertain because of ticlopidine's complex activation.
What this interaction means in plain words
Ticlopidine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ticlopidine belongs to Cardiovascular; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, potentially altering ticlopidine metabolism.
What to do
Consider an alternative antiplatelet. If coadministered, monitor blood counts and for adverse effects of ticlopidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Ticlopidine with Voxelotor?
MediHelp rates the interaction as moderate. Ticlopidine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can raise exposure of sensitive CYP3A4 substrates. Ticlopidine is partly metabolized by CYP3A4, so exposure may change. The clinical significance is uncertain because of ticlopidine's complex activation.
How serious is the interaction between Ticlopidine and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiplatelet. If coadministered, monitor blood counts and for adverse effects of ticlopidine.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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