Drug interactions
Ticlopidine + Warfarin
Severity: Major
Ticlopidine and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits platelet aggregation and adds bleeding risk to warfarin. It also inhibits CYP2C19 and may modestly raise warfarin exposure; hematologic toxicity adds further risk.
What this interaction means in plain words
Ticlopidine and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ticlopidine belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Additive antiplatelet and anticoagulant effects with inhibition of warfarin metabolism.
What to do
Avoid combining where possible; if necessary, monitor INR and blood counts closely and adjust warfarin dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Ticlopidine with Warfarin?
MediHelp rates the interaction as major. Ticlopidine and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits platelet aggregation and adds bleeding risk to warfarin. It also inhibits CYP2C19 and may modestly raise warfarin exposure; hematologic toxicity adds further risk.
How serious is the interaction between Ticlopidine and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary, monitor INR and blood counts closely and adjust warfarin dose.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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