Drug interactions
Tinidazole + Tucatinib
Severity: Moderate
Tinidazole and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may increase tinidazole exposure. This could increase dose-related adverse effects of tinidazole, though the clinical impact is not well characterized.
What this interaction means in plain words
Tinidazole and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tinidazole belongs to Anti Parasitic; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing the metabolic clearance of tinidazole.
What to do
Monitor for tinidazole adverse effects such as nausea, dizziness and neuropathy. Keep the tinidazole course as short as the indication allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tinidazole with Tucatinib?
MediHelp rates the interaction as moderate. Tinidazole and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may increase tinidazole exposure. This could increase dose-related adverse effects of tinidazole, though the clinical impact is not well characterized.
How serious is the interaction between Tinidazole and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tinidazole adverse effects such as nausea, dizziness and neuropathy. Keep the tinidazole course as short as the indication allows.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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